Volume 50, Issue 6 (November 2005)

    Diagnosis of Alzheimer's Disease in an Exhumed Decomposed Brain After Twenty Months of Burial in a Deep Grave

    (Received 26 March 2005; accepted 25 June 2005)

    Published Online: September

    CODEN: JFSOAD

      Format Pages Price  
    PDF Version 6 $25   ADD TO CART


    Abstract

    After 20 months of interment in a deep grave, the decomposed body of the 81-year old testator of a will was exhumed to sustain the burden of proof that he lacked testamentary capacity when the will was rewritten two days prior to his death. The brain was mushy and pulverized with complete disappearance of the brainstem, cerebellum and subcortical ganglia. Small foci of relatively intact dorsal frontal neocortex were identified. Sections from these foci were stained with hematoxylin and eosin, bielchowsky silver stain and immunostains for beta amyloid peptide (βA4), tau and alpha-synuclein. Despite severe autolysis and decomposition, the bielchowsky stain and the βA4 immunostains showed preserved frequent neuritic amyloid plaques with very few residual neurofibrillary tangles. Cerebral Amyloid Angiopathy was present. At the present time this case represents the first documented and reported case of direct tissue diagnosis of Alzheimer's Disease pathology in a decomposed brain following long term burial in a deep grave.


    Author Information:

    Omalu, BL
    Divisions of Forensic Pathology and Forensic Neuropathology, Pittsburgh, PA

    Wecht, CH
    Divisions of Forensic Pathology and Forensic Neuropathology, Pittsburgh, PA

    Mancuso, JA
    Carlow University, Pittsburgh, PA

    Cho, P
    Allegheny General Hospital, Pittsburgh, PA


    Stock #: JFS2005160

    ISSN: 0022-1198

    DOI: 10.1520/JFS2005160

    ASTM International
    is a member of CrossRef.

    Author
    Title Diagnosis of Alzheimer's Disease in an Exhumed Decomposed Brain After Twenty Months of Burial in a Deep Grave
    Symposium , 0000-00-00
    Committee E30