Volume 50, Issue 5 (September 2005)

    Expression of Seminal Vesicle-Specific Antigen in Serum of Lung Tumor Patients

    (Received 9 October 2004; accepted 9 April 2005)

    Published Online: August

    CODEN: JFSOAD

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    Abstract

    Protein markers are commonly used in forensic medicine to establish the origin of human fluids detected in crime scenes. Semenogelins, the major protein constituents of semen coagulum, are the most effective markers for semen detection. Recently, it has been demonstrated that semenogelins are also ectopically expressed in small cell lung carcinomas (SCLC) and in a minority of non-small cell lung carcinomas (NSCLC). This finding prompted us to look for semenogelin expression in the serum of lung cancer patients. A set of 13 serum samples (3 from SCLC and 10 from NSCLC patients) was screened by enzyme—linked immunosorbent assay (ELISA), using a commercially available kit. Four of the NSCLC cases showed positive results. Ectopic expression of marker proteins in individuals affected by cancer could represent a potential source of forensic pitfalls.


    Author Information:

    Berti, A
    Scientific Investigation Department of Rome, Rome,

    Cavazzana, A
    University of Pisa, PISA,

    Virgili, A
    Scientific Investigation Department of Rome, Rome,

    D'Errico, G
    Scientific Investigation Department of Rome, Rome,

    Lago, G
    Scientific Investigation Department of Rome, Rome,

    Vespi, G
    Scientific Investigation Department of Rome, Rome,


    Stock #: JFS2004446

    ISSN: 0022-1198

    DOI: 10.1520/JFS2004446

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    Author
    Title Expression of Seminal Vesicle-Specific Antigen in Serum of Lung Tumor Patients
    Symposium , 0000-00-00
    Committee E30