Volume 49, Issue 6 (November 2004)

    Commentary on: Budowle B, Shea B, Niezgoda S, Chakraborty R. CODIS STR loci data from 41 sample populations. L Forensic Sci 2001;46:453–489.

    Published Online: November

    CODEN: JFSOAD

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    Abstract

    Sir: In an article on allele frequencies for CODIS loci in 41 different populations, Budowle et al. (1) reported no significant deviations from Hardy-Weinberg expectations (HWE) after making the Bonferroni correction for multiple tests. However, examination of the data reported in (1) for two Native American populations, Navaho and Salishan, shows significant departures from HWE at three loci for each population. Budowle et al. appear to have relied on an incorrect and unsupportable application of the Bonferroni correction (2,3) to disregard these deviations. These loci should not be used when the product rule is employed to compute the frequency of multi-locus genotypes in these populations unless appropriate corrective actions are taken to account for the observed deviations from HWE.


    Stock #: JFS2004162

    ISSN: 0022-1198

    DOI: 10.1520/JFS2004162

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    Author
    Title Commentary on: Budowle B, Shea B, Niezgoda S, Chakraborty R. CODIS STR loci data from 41 sample populations. L Forensic Sci 2001;46:453–489.
    Symposium , 0000-00-00
    Committee E30