Postmortem Tissue Distribution of Olanzapine and Citalopram in a Drug Intoxication

    Volume 50, Issue 3 (May 2005)

    ISSN: 0022-1198

    CODEN: JFSOAD

    Published Online: 6 April 2005

    Page Count: 3


    Jenkins, AJ
    The Office of the Cuyahoga County Coroner, Cleveland, OH

    Horak, EL
    The Office of the Cuyahoga County Coroner, Cleveland, OH

    (Received 22 February 2004; accepted 6 November 2004)

    Abstract

    A 40-year-old white male was found dead in bed in a group home for mentally ill adults. The decedent had been diagnosed a paranoid schizophrenic. An autopsy was performed at the Office of the Cuyahoga County Coroner in Cleveland, Ohio. Toxicological testing detected olanzapine and citalopram in post mortem specimens. Multiple fluids and tissues were assayed by liquid-liquid extraction followed by gas chromatography with nitrogen phosphorus detection, and qualitative confirmation by electron impact gas chromatography/mass spectrometry. Drug concentrations [olanzapine : citalopram; mg/L or mg/Kg] determined in this case are the highest reported to date involving these drugs- 1.38:3.35 heart blood, 1.11:1.65 femoral blood, 60.24:32.43 urine, 6.47:10:71 liver, and 38.36:49.16 lung, respectively. Drug concentrations in tissues were found to be the highest in lung for both drugs and lowest in the heart. Citalopram but not olanzapine was detected in bone. The cause of death was ruled acute intoxication by the combined effects of olanzapine and citalopram and the manner, accident.


    Paper ID: JFS2004067

    DOI: 10.1520/JFS2004067

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    Author
    Title Postmortem Tissue Distribution of Olanzapine and Citalopram in a Drug Intoxication
    Symposium , 0000-00-00
    Committee E30