Specificity of Sibship Determination Using the ABI Identifiler Multiplex System

    Volume 49, Issue 6 (November 2004)

    ISSN: 0022-1198

    CODEN: JFSOAD

    Published Online: 1 November 2004

    Page Count: 3


    Wolf, CA
    DNA Diagnostics Center, Fairfield, OH

    Kraemer, CM
    DNA Diagnostics Center, Fairfield, OH

    Baird, ML
    DNA Diagnostics Center, Fairfield, OH

    Lee, RF
    DNA Diagnostics Center, Fairfield, OH

    Lee, SC
    DNA Diagnostics Center, Fairfield, OH

    Reid, TM
    DNA Diagnostics Center, Fairfield, OH

    (Received 8 February 2004; accepted 5 June 2004)

    Abstract

    Fifty known siblings and fifty unrelated pairs were genotyped using the ABI Identifiler STR system and sibship indices computed for each pair. Combined sibship indices (CSIs) for the known siblings ranged from less than 10 to greater than 1 billion. CSIs for the unrelated pairs ranged from 4.5 x 10-8 to 0.12. In the known sibling group the percentage of loci where both alleles matched was approximately 40%, while the percentage of loci where neither matched was approximately 10%. In the non-sibling group, the percentage of loci where both alleles matched was approximately 6%, while the percentage of loci where neither matched was approximately 45%. Interestingly, the percentage of loci where a single allele matched was the same in both the known siblings and unrelated pairs, approximately 50%.


    Paper ID: JFS2004041

    DOI: 10.1520/JFS2004041

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    Author
    Title Specificity of Sibship Determination Using the ABI Identifiler Multiplex System
    Symposium , 0000-00-00
    Committee E30