Trace Analysis of Peroxide Explosives by High Performance Liquid Chromatography-Atmospheric Pressure Chemical Ionization-Tandem Mass Spectrometry (HPLC-APCI-MS/MS) for Forensic Applications

    Volume 49, Issue 6 (November 2004)

    ISSN: 0022-1198

    CODEN: JFSOAD

    Published Online: 1 November 2004

    Page Count: 7


    van de Craats, AM
    Netherlands Forensic Institute,

    Kok, EM
    Netherlands Forensic Institute,

    de Bruyn, PCAM
    Netherlands Forensic Institute,

    Xu, X
    Netherlands Forensic Institute,

    (Received 30 December 2003; accepted 20 June 2004)

    Abstract

    An HPLC-APCI-MS(/MS) method for the (trace) analysis of the most commonly encountered peroxide explosives, hexamethylenetriperoxidediamine (HMTD) and triacetonetriperoxide (TATP), has been developed. With this method, HMTD and TATP have been analyzed in the same run. (Pseudo-)molecular ions of these peroxides have been obtained as base peak under the same condition. A series of product ions was produced from these pseudo-molecular ions ([HMTD-1]+ and [TATP + NH4]+) in the MS/MS analysis. We also pioneeredin showing that TATP molecular ion [TATP-H] can be observed with HPLC-MS/MS. The limit of detection for HMTD and TATP was 0.26 and 3.3 ng, respectively, on column by HPLC-MS in the Full Scan mode and 0.08 and 0.8, respectively, by HPLC-APCI-MS/MS in Selected Reaction Monitoring (single ass unit) mode. The method presented has been applied successfully for the identification of peroxides in the bulk solid state (powder sample), as well as in post-blast extracts originating from a forensic case. For the post-blast extracts, the use of tandem MS has been shown clearly to be of crucial importance for the identification and detection of the peroxide explosives.


    Paper ID: JFS2003440

    DOI: 10.1520/JFS2003440

    ASTM International
    is a member of CrossRef.

    Author
    Title Trace Analysis of Peroxide Explosives by High Performance Liquid Chromatography-Atmospheric Pressure Chemical Ionization-Tandem Mass Spectrometry (HPLC-APCI-MS/MS) for Forensic Applications
    Symposium , 0000-00-00
    Committee E30