Informativeness of the CODIS STR Loci for Admixture Analysis

    Volume 50, Issue 6 (November 2005)

    ISSN: 0022-1198

    CODEN: JFSOAD

    Published Online: 31 August 2005

    Page Count: 5


    Pfaff, CL
    University of Michigan Medical School, Ann Arbor, MI

    Long, JC
    University of Michigan Medical School, Ann Arbor, MI

    Barnholtz-Sloan, JS

    Chakraborty, R
    University of Cincinnati, Cincinnati, OH

    (Received 10 December 2003; accepted 14 May 2005)

    Abstract

    Population admixture (or ancestry) is used as an approach to gene discovery in complex diseases, particularly when the disease prevalence varies widely across geographic populations. Admixture analysis could be useful for forensics because an indication of a perpetrator's ancestry would narrow the pool of suspects for a particular crime. The purpose of this study was to use Fisher's information to identify informative sets of markers for admixture analysis. Using published founding population allele frequencies we test three marker sets for efficacy for estimating admixture: the FBI CODIS Core STR loci, the HGDP-CEPH Human Genome Diversity Cell Line Panel and the set of 39 ancestry informative SNPS from the Shriver lab at Pennsylvania State University. We conclude that the FBI CODIS Core STR set is valid for admixture analysis, but not the most precise. We recommend using a combination of the most informative markers from the HGDP-CEPH and Shriver loci sets.


    Paper ID: JFS2003404

    DOI: 10.1520/JFS2003404

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    Author
    Title Informativeness of the CODIS STR Loci for Admixture Analysis
    Symposium , 0000-00-00
    Committee E30