Volume 49, Issue 6 (November 2004)

    Characterization of Allegedly Musk-Containing Medicinal Products in Taiwan

    (Received 8 November 2003; accepted 7 May 2004)

    Published Online: November

    CODEN: JFSOAD

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    Abstract

    As a highly valued ingredient of Chinese medicinal remedies, musk is used as a detoxification agent and for treating fever, inflammation and swelling, and pain. Muscone (3-methylcyclopentadecanone-1), an odoriferous secretion from the ventral glands of male musk deer, is believed to be the active ingredient. A small amount of muscopyridine is also found in the secretion from the ventral glands of male musk deer. Common counterfeit ingredients are musk xylene, musk ambrette, musk ketone, and diphenhydramine. An extraction/GC-MS protocol/data evaluation scheme was developed and applied to study allegedly musk-containing Musk-Tiger Bone Plaster preparations and musk pods (or grains) from Chinese medicine stores and an airport customs. The content of muscone in a specific sample was estimated based on the percentage of the amount recovered from the first extraction. No muscone or counterfeit ingredients were found in all musk pod (or grain) samples from the customs and in the majority of Musk-Tiger Bone Plaster preparations, while muscone (alone or with counterfeit ingredients) was found in most of the musk pod (or grain) collected from Chinese medicine stores.


    Author Information:

    Lin, DL
    Institute of Forensic Medicine, Ministry of Justice, Taipei, Taiwan (ROC), and Taipei Medical University, Taipei,

    Chang, HC
    China Medical University, Taichung,

    Huang, SH
    Ministry of Justice Investigation Bureau, Taipei,


    Stock #: JFS2003381

    ISSN: 0022-1198

    DOI: 10.1520/JFS2003381

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    Author
    Title Characterization of Allegedly Musk-Containing Medicinal Products in Taiwan
    Symposium , 0000-00-00
    Committee E30