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    Volume 50, Issue 1 (January 2005)

    Pancuronium Bromide (Pavulon) Isolation and Identification in Aged Autopsy Tissues and Fluids

    (Received 25 January 2003; accepted 31 July 2004)

    Published Online: January

    CODEN: JFSOAD

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    Abstract

    The isolation and detection of pancuronium bromide was developed for aged autopsy samples to identify and confirm this compound in questioned tissue samples. A novel protocol was optimized for the isolation of the target drug in highly decomposed tissues. Solid-phase extraction (SPE) cartridges containing styrene-divinylbenzene were investigated. This polymer retained quaternary drugs and facilitated sequential elution upon washing with commonly available solvents. The semi-purified SPE samples were prescreened by pyrolysis GC-MS. A candidate specimen was then confirmed by microbore high-performance liquid chromatography/electrospray-ionization/mass spectrometry (µHPLC-ESI-MS/MS) with a triple-quadrupole mass spectrometer. The developed procedures provided a qualitative or semiquantitative (at best) basis for the investigation of difficult cases involving overdoses of polar drugs.


    Author Information:

    Alcaraz, A
    Forensic Science Center, Livermore National Laboratory, Livermore, CA.

    Andresen, BD
    Forensic Science Center, Livermore National Laboratory, Livermore, CA.

    Grant, PM
    Forensic Science Center, Livermore National Laboratory, Livermore, CA.


    Stock #: JFS2003352

    ISSN: 0022-1198

    DOI: 10.1520/JFS2003352

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    Author
    Title Pancuronium Bromide (Pavulon) Isolation and Identification in Aged Autopsy Tissues and Fluids
    Symposium , 0000-00-00
    Committee E30