Volume 49, Issue 3 (May 2004)
Sir: Thank you for the comments regarding our article A fatal drug interaction between oxycodone and clonazepam. The commentary states that the authors seem to base their statement of a fatal drug interaction on a metabolic interaction between oxycodone and clonazepam. The second paragraph of the introductory section postulates not only mechanisms of metabolic hindrance by competitive substrates (clonazepam and oxycodone), but also by other drugs (cannabinoids) and pathologies present in this particular subject. In our conclusions, we also state the concentrations of oxycodone and clonazepam observed may have resulted from either an acute administration of a particular dosage and/or an attenuated metabolism.