Volume 49, Issue 6 (November 2004)

    The Reactivity of Gamma-hydroxybutyric acid (GHB) and Gamma-butyrolactone (GBL) in Alcoholic Solutions

    (Received 12 October 2003; accepted 12 June 2004)

    Published Online: November

    CODEN: JFSOAD

      Format Pages Price  
    PDF Version 10 $25   ADD TO CART


    Abstract

    In this work the stability of GBL (gamma-butyrolactone) and GHB (gamma-hydroxybutyric acid) in alcoholic media was studied. Under acidic conditions the GBL will react with ethanol or methanol to give the corresponding ethyl and methyl esters of GHB. It can be seen that ester formation is dependent on the type of alcohol, the alcohol content of the solution, and the pH of the solution. Under the same conditions it was shown that GHB does not give rise directly to the corresponding ester when merely in the presence of an alcohol; however the ester will be formed if the conditions are present for conversion of GHB to GBL followed by subsequent reaction with alcohol. In alcoholic beverage samples spiked with GBL the expected conversion to GHB occurred, and the formation of the ethyl ester of GHB was also seen in some samples. Wine samples were analyzed for the presence of the ethyl ester of GHB, and the effect of adding GHB/GBL to hot beverages was studied.


    Author Information:

    Hennessy, S A
    Limerick Institute of Technology, Limerick,

    McDermott, S D
    Forensic Science Laboratory Garda H.Q, Dublin 8,

    Moane, S M
    Limerick Institute of Technology, Limerick,


    Stock #: JFS2003340

    ISSN: 0022-1198

    DOI: 10.1520/JFS2003340

    ASTM International
    is a member of CrossRef.

    Author
    Title The Reactivity of Gamma-hydroxybutyric acid (GHB) and Gamma-butyrolactone (GBL) in Alcoholic Solutions
    Symposium , 0000-00-00
    Committee E30