Journal Published Online: 01 November 2003
Volume 48, Issue 6

New Developments in SPME, Part 1: The Use of Vapor-Phase Deprotonation and On-Fiber Derivatization with Alkylchloroformates in the Analysis of Preparations Containing Amphetamines

CODEN: JFSCAS

Abstract

Due to their high polarity and low vapor pressure, most amine salts of amphetamine-type drugs are not directly amenable to headspace recovery using solid-phase microextraction (SPME). Described in this article is a simple vapor-phase procedure for the conversion of solid drug salt samples into their free bases by the use of triethylamine. This process can be conducted simultaneously with headspace SPME, the outcome being that solid drug salts can be sampled directly for GC-MS without the need for dissolution and chemical processing. Potential applications for this methodology include the noninvasive recovery of drug traces from objects such as banknotes and garments.

This new process for recovery of amphetamine-type drugs has been combined with on-fiber derivatization using alkylchloroformates. This extra step was included to improve the chromatographic performance of analytes and allow for the resolution of drug enantiomers.

Author Information

Brown, HB
Flinders University of South Australia, Adelaide, South Australia
Kirkbride, KP
Forensic Science, South Australia, Adelaide, South Australia
Pigou, PE
Forensic Science, South Australia, Adelaide, South Australia
Walker, GS
Flinders University of South Australia, Adelaide, South Australia
Pages: 8
Price: $25.00
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Stock #: JFS2003117
ISSN: 0022-1198
DOI: 10.1520/JFS2003117