New Developments in SPME, Part 1: The Use of Vapor-Phase Deprotonation and On-Fiber Derivatization with Alkylchloroformates in the Analysis of Preparations Containing Amphetamines

    Volume 48, Issue 6 (November 2003)

    ISSN: 0022-1198

    CODEN: JFSOAD

    Published Online: 1 November 2003

    Page Count: 8


    (Received 18 June 2003; accepted 15 June 2003)

    Abstract

    Due to their high polarity and low vapor pressure, most amine salts of amphetamine-type drugs are not directly amenable to headspace recovery using solid-phase microextraction (SPME). Described in this article is a simple vapor-phase procedure for the conversion of solid drug salt samples into their free bases by the use of triethylamine. This process can be conducted simultaneously with headspace SPME, the outcome being that solid drug salts can be sampled directly for GC-MS without the need for dissolution and chemical processing. Potential applications for this methodology include the noninvasive recovery of drug traces from objects such as banknotes and garments.

    This new process for recovery of amphetamine-type drugs has been combined with on-fiber derivatization using alkylchloroformates. This extra step was included to improve the chromatographic performance of analytes and allow for the resolution of drug enantiomers.


    Paper ID: JFS2003117

    DOI: 10.1520/JFS2003117

    ASTM International
    is a member of CrossRef.

    Author
    Title New Developments in SPME, Part 1: The Use of Vapor-Phase Deprotonation and On-Fiber Derivatization with Alkylchloroformates in the Analysis of Preparations Containing Amphetamines
    Symposium , 0000-00-00
    Committee E30