Mutation in the STR Locus D21S11 of Father Causing Allele Mismatch in the Child

    Volume 49, Issue 1 (January 2004)

    ISSN: 0022-1198

    CODEN: JFSOAD

    Published Online: 23 December 2003

    Page Count: 5


    Reddy, AD
    Centre for Cellular and Molecular Biology, Hyderabad,

    Thangaraj, K
    Centre for Cellular and Molecular Biology, Hyderabad,

    Singh, L
    Centre for Cellular and Molecular Biology, Hyderabad,

    (Received 8 July 2002; accepted 20 September 2003)

    Abstract

    We analyzed a case of paternity dispute with 15 autosomal STR loci and found a mismatch in one of the alleles of the locus D21S11 in the child. The composition of the alleles of this locus in the mother, suspicious father, and child were 29/32, 29/29, and 29/30, respectively. The combined paternity index (2.4×1010) and paternity probability (0.9999) suggest that the suspicious father is the biological father of the child. Further analysis of 6 Y chromosome STR loci revealed matching of all the Y chromosomal alleles of the child with that of the suspicious father. Since there was a perfect match of all the paternal alleles inherited (15 autosomal and 6 Y chromosomal) in the child with that of the suspicious father except the allele D21S11, it is suggested that this might be a case of mutation. Cloning and sequencing of all the alleles of the locus D21S11 of the suspicious father, mother, and the child helped in determining that the suspicious father contributed the mutated allele.


    Paper ID: JFS2002236

    DOI: 10.1520/JFS2002236

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    Author
    Title Mutation in the STR Locus D21S11 of Father Causing Allele Mismatch in the Child
    Symposium , 0000-00-00
    Committee E30