Journal Published Online: 01 January 2003
Volume 48, Issue 1

Characterization of a Novel Dimorphism in the 5‵ Flanking Region of the Short Tandem Repeat (STR) Locus, (FES)

CODEN: JFSCAS

Abstract

The FES short tandem repeat (STR) locus contains seven to 14 repeats of the tetranucleotide sequence ATTT. A novel 10 base pair dimorphism in the 5' flanking region of the FES locus was characterized in four broad populations: African-American, Hispanic, Caucasian, and Asian. The absence of the 10 base pair sequence, or (−) allele, was closely linked to FES STR alleles with 10 or fewer repeats. The presence of the 10 base pair sequence, or (+) allele, was closely linked to FES STR alleles with 12 or more repeats. The (−) and (+) alleles occurred equally often in FES STR allele11. The nucleotide sequence (5'-GGCTGTTTTG-3') of the (+) allele, located 179 base pairs upstream of the FES STR, was determined to be consistent within and among the four populations. Statistical and sequence analysis confirmed the linkage between the two polymorphic sites. The results indicate that the exclusion rate of the FES locus is increased, above that for the STR alone, when both polymorphic characteristics are considered.

Author Information

Bieschke, ET
Office of the Chief Medical Examiner, New York, NY
Wallace, MM
City University of New York, New York, NY
De Forest, PR
City University of New York, New York, NY
Shaler, RC
Office of the Chief Medical Examiner, New York, NY
Prinz, M
Office of the Chief Medical Examiner, New York, NY
Pages: 3
Price: $25.00
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Stock #: JFS2002065
ISSN: 0022-1198
DOI: 10.1520/JFS2002065