Volume 48, Issue 1 (January 2003)

    Characterization of a Novel Dimorphism in the 5‵ Flanking Region of the Short Tandem Repeat (STR) Locus, c-fes/fps (FES)

    (Received 16 July 2002; accepted 30 June 2002)

    Published Online: January

    CODEN: JFSOAD

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    Abstract

    The FES short tandem repeat (STR) locus contains seven to 14 repeats of the tetranucleotide sequence ATTT. A novel 10 base pair dimorphism in the 5' flanking region of the FES locus was characterized in four broad populations: African-American, Hispanic, Caucasian, and Asian. The absence of the 10 base pair sequence, or (−) allele, was closely linked to FES STR alleles with 10 or fewer repeats. The presence of the 10 base pair sequence, or (+) allele, was closely linked to FES STR alleles with 12 or more repeats. The (−) and (+) alleles occurred equally often in FES STR allele11. The nucleotide sequence (5'-GGCTGTTTTG-3') of the (+) allele, located 179 base pairs upstream of the FES STR, was determined to be consistent within and among the four populations. Statistical and sequence analysis confirmed the linkage between the two polymorphic sites. The results indicate that the exclusion rate of the FES locus is increased, above that for the STR alone, when both polymorphic characteristics are considered.


    Author Information:

    Bieschke, ET
    Office of the Chief Medical Examiner, New York, NY

    Wallace, MM
    City University of New York, New York, NY

    Prinz, M
    Office of the Chief Medical Examiner, New York, NY

    De Forest, PR
    City University of New York, New York, NY

    Shaler, RC
    Office of the Chief Medical Examiner, New York, NY


    Stock #: JFS2002065

    ISSN: 0022-1198

    DOI: 10.1520/JFS2002065

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    Author
    Title Characterization of a Novel Dimorphism in the 5‵ Flanking Region of the Short Tandem Repeat (STR) Locus, c-fes/fps (FES)
    Symposium , 0000-00-00
    Committee E30