Fatal Parvovirus B19 Myocarditis in an 8-Year-Old Boy

    Volume 48, Issue 1 (January 2003)

    ISSN: 0022-1198


    Published Online: 1 January 2002

    Page Count: 4

    Eisü-Hubinger, AM
    University of Bonn,

    Baasner, A
    University of Bonn,

    Madea, B
    University of Bonn,

    Dettmeyer, R
    University of Bonn,

    Kandolf, R
    University Hospital of Tubingen,

    Banaschak, S
    University of Bonn,


    A report is given on an 8-year-old boy who suddenly and unexpected died. Autopsy findings point to acute heart failure. Microscopic examination of the heart showed increased interstitial and perivasal fibrosis and myocarditis with macrophage infiltration. Polymerase chain reaction (PCR) analysis for parvovirus B19 was positive in heart samples and in the spleen. Immunostaining for parvoviral surface antigens was negative. Although the virus does not appear to have infected the cardiomyocytes, we speculate that myocarditis arose from immunological cross-reaction to epitopes shared between the virus and the myocardium.

    Paper ID: JFS2002009

    DOI: 10.1520/JFS2002009

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    Title Fatal Parvovirus B19 Myocarditis in an 8-Year-Old Boy
    Symposium , 0000-00-00
    Committee E30