ISSN: 0022-1198
CODEN: JFSCA
Published Online: 1 January 2002
Page Count: 4

Fatal Parvovirus B19 Myocarditis in an 8-Year-Old Boy
Eisü-Hubinger, AM
University of Bonn,

Baasner, A
University of Bonn,

Madea, B
University of Bonn,

Dettmeyer, R
University of Bonn,

Kandolf, R
University Hospital of Tubingen,

Banaschak, S
University of Bonn,

Abstract

A report is given on an 8-year-old boy who suddenly and unexpected died. Autopsy findings point to acute heart failure. Microscopic examination of the heart showed increased interstitial and perivasal fibrosis and myocarditis with macrophage infiltration. Polymerase chain reaction (PCR) analysis for parvovirus B19 was positive in heart samples and in the spleen. Immunostaining for parvoviral surface antigens was negative. Although the virus does not appear to have infected the cardiomyocytes, we speculate that myocarditis arose from immunological cross-reaction to epitopes shared between the virus and the myocardium.

Keywords:
forensic science, myocarditis, parvovirus B19, immunohistochemistry, nested PCR

Paper ID: JFS2002009
DOI: 10.1520/JFS2002009
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