Volume 48, Issue 1 (January 2003)

    Fatal Parvovirus B19 Myocarditis in an 8-Year-Old Boy

    Published Online: January


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    A report is given on an 8-year-old boy who suddenly and unexpected died. Autopsy findings point to acute heart failure. Microscopic examination of the heart showed increased interstitial and perivasal fibrosis and myocarditis with macrophage infiltration. Polymerase chain reaction (PCR) analysis for parvovirus B19 was positive in heart samples and in the spleen. Immunostaining for parvoviral surface antigens was negative. Although the virus does not appear to have infected the cardiomyocytes, we speculate that myocarditis arose from immunological cross-reaction to epitopes shared between the virus and the myocardium.

    Author Information:

    Eisü-Hubinger, AM
    University of Bonn,

    Baasner, A
    University of Bonn,

    Madea, B
    University of Bonn,

    Dettmeyer, R
    University of Bonn,

    Kandolf, R
    University Hospital of Tubingen,

    Banaschak, S
    University of Bonn,

    Stock #: JFS2002009

    ISSN: 0022-1198

    DOI: 10.1520/JFS2002009

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    Title Fatal Parvovirus B19 Myocarditis in an 8-Year-Old Boy
    Symposium , 0000-00-00
    Committee E30