Drug Concentration in Selected Skeletal Muscles

    Volume 43, Issue 1 (January 1998)

    ISSN: 0022-1198

    CODEN: JFSOAD

    Published Online: 1 January 1998

    Page Count: 6


    Langford, AM
    Scientific Officer, Research Assistant, and Professor of Forensic Medicine, University of Dundee,

    Pounder, DJ
    Scientific Officer, Research Assistant, and Professor of Forensic Medicine, University of Dundee,

    Taylor, KK
    Scientific Officer, Research Assistant, and Professor of Forensic Medicine, University of Dundee,

    (Received 27 February 1997; accepted 24 April 1997)

    Abstract

    We evaluated the homogeneity of drug concentrations in muscle in 14 cadavers, comprising 11 drug overdoses and three cases of chronic therapeutic drug use. Analyses were performed on samples from twelve named muscles and femoral venous blood. Standard analytical techniques and instrumentation were used throughout. There was marked within-case variability in drug concentrations with highest:lowest concentrations ranging up to 21.7. Overall highest concentrations were found in the diaphragm and mean diaphragm:blood ratios ranged from 1.1 (temazepam, two cases) and 1.2/1.3 (paracetamol, six cases) up to 6.5/13.5 (amitriptyline, three cases) and 5.3/21.3 (propoxyphene, four cases). Excluding the diaphragm, mean muscle:blood ratios ranged from 0.4 (prothiaden), 0.5 (temazepam), and 0.7 (paracetamol) up to 3.7 (temazepam), 4.3 (propoxyphene) and 5.7 (amitriptyline). We suggest that muscle is suitable for qualitative analysis but not for quantitative corroboration of a blood sample or as a quantitative alternative to blood.


    Paper ID: JFS16084J

    DOI: 10.1520/JFS16084J

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    Author
    Title Drug Concentration in Selected Skeletal Muscles
    Symposium , 0000-00-00
    Committee E30