Volume 47, Issue 6 (November 2002)

    Enantiomeric Separation of Methamphetamine and Related Analogs by Capillary Zone Electrophoresis: Intelligence Study in Routine Methamphetamine Seizures

    (Received 14 June 2002; accepted 11 May 2002)

    Published Online: November

    CODEN: JFSOAD

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    Abstract

    A method for simultaneous enantiomeric separation of ephedrine, pseudoephedrine, and methamphetamine (MA) in a single run by simple capillary zone electrophoresis (CZE) with β-cyclodextrin as a chiral selector is described. The effects of the buffer pH, phosphate concentration, β-cyclodextrin concentration, voltage and temperature on the peak resolution were examined. Good enantiomeric resolution was attained for each analyte under our optimized conditions: 15 mM β-cyclodextrin, 300 mM NaH2PO4 at pH 2.5 with an uncoated capillary (64.5 cm × 50 m), applied potential at 20 kV and temperature at 30°C. Ultraviolet (UV) detection at a fixed wavelength (200 nm) was employed using a diode array detector. Using phentermine as an internal standard, migration times for all analytes are reproducible within 0.1% for intra-day and 0.6% for inter-day runs. Application of this method to the analysis of confiscated drugs is discussed.


    Author Information:

    Dao, KL
    Chemist, Chemist, Senior Chemist, Senior Chemist, and Chemist, respectively, Homantin Government Offices, Homantin,

    Chan, MF
    Chemist, Chemist, Senior Chemist, Senior Chemist, and Chemist, respectively, Homantin Government Offices, Homantin,

    Tsui, P
    Chemist, Chemist, Senior Chemist, Senior Chemist, and Chemist, respectively, Homantin Government Offices, Homantin,

    Cheng, WC
    Chemist, Chemist, Senior Chemist, Senior Chemist, and Chemist, respectively, Homantin Government Offices, Homantin,

    Lee, WM
    Chemist, Chemist, Senior Chemist, Senior Chemist, and Chemist, respectively, Homantin Government Offices, Homantin,


    Stock #: JFS15556J

    ISSN: 0022-1198

    DOI: 10.1520/JFS15556J

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    Title Enantiomeric Separation of Methamphetamine and Related Analogs by Capillary Zone Electrophoresis: Intelligence Study in Routine Methamphetamine Seizures
    Symposium , 0000-00-00
    Committee E30