Volume 47, Issue 5 (September 2002)

    The Behavioral and Cognitive Effects of Two Benzodiazepines Associated with Drug-Facilitated Sexual Assault

    (Received 26 March 2002; accepted 22 March 2002)

    Published Online: September

    CODEN: JFSOAD

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    Abstract

    Recently, sexual assaults have included the use of benzodiazepines to impair the victim. Our aim was to examine the physiological, cognitive, and behavioral effects of flunitrazepam (FN) and clonazepam (CLO). In the first study, ten healthy volunteers received a single oral dose of 2 mg of FN. Mini Mental State Examination (MMSE), behavioral reports and staff observations were then collected. In the second study, ten healthy volunteers received a single oral dose of 3 mg of CLO. Vitals signs, performance on the MMSE and Digit Symbol Substitution Test, and behavioral changes were examined. FN significantly decreased systolic and diastolic blood pressure 4 h post drug ingestion with diastolic remaining low at 6 h. CLO was associated with changes in temperature and decreased systolic pressure. FN affected memory and attention 4 h following ingestion. CLO affected memory and attention throughout the study (6 h), and psychomotor performance was decreased 2 h post ingestion. In both studies, subjects were disinhibited and did not perceive their own impairment.


    Author Information:

    Negrusz, A
    College of Pharmacy, University of Illinois at Chicago (UIC),

    Strong, MJ
    College of Medicine, University of Illinois at Chicago, Chicago, IL

    Janicak, PG
    College of Medicine, University of Illinois at Chicago, Chicago, IL

    Dowd, SM
    College of Medicine, University of Illinois at Chicago, Chicago, IL


    Stock #: JFS15522J

    ISSN: 0022-1198

    DOI: 10.1520/JFS15522J

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    Author
    Title The Behavioral and Cognitive Effects of Two Benzodiazepines Associated with Drug-Facilitated Sexual Assault
    Symposium , 0000-00-00
    Committee E30