Volume 47, Issue 4 (July 2002)
Postmortem Concentrations of Citalopram
The postmortem concentrations of citalopram in blood, bile, liver, and vitreous humour were investigated in 14 cases using a spe-cially developed high performance liquid chromatography assay. Concentrations from drug and non-drug related deaths were categorized to deter-mine a postmortem therapeutic and toxic range. Therapeutic citalopram concentrations for blood, bile, liver, and vitreous humour ranged to 0.4 mg/L, 2.1 mg/l, 6.6 mg/kg, and 0.2 mg/L, respectively. In one potentially fatal response to citalopram, concentrations were 0.8 mg/L, 6.0 mg/L, 0.3 mg/L for blood, bile and vitreous humour, respectively.