Volume 41, Issue 2 (March 1996)

    Poppy Seeds: Differences in Morphine and Codeine Content and Variation in Inter- and Intra-Individual Excretion

    CODEN: JFSOAD

      Format Pages Price  
    PDF Version 4 $25   ADD TO CART


    Abstract

    Poppy seeds from seven different origins (Dutch, Australian, Hungarian, Spanish, Czech, and two Turkish) were analyzed for the amount of opiates present. Four grams of each kind of seeds, equivalent to the amount of seeds on two bagels, were ingested by volunteers. One volunteer also ingested four times the same amount of poppy seeds from the same origin (Spanish). During 24 hours urine samples were obtained and screened for the presence of morphine and codeine using the FPIA technique (cut-off = 200 ng/mL) and a GC/MS confirmation with a limit of detection (LOD) of 25 ng/mL for codeine and morphine. Poppy seeds from different origins contain a wide variation of morphine (2–251 µg/g) and codeine (0.4–57.1 µg/g) content. No other opiate could be detected. After ingestion a large interindividual variation of excretion of opiates exists. The testing results from the same kind of seeds ingested four times with a one week interval by the same volunteer also show a poor reproduceability. Several kinds of poppy seeds can give positive testing results (Australian, Hungarian, spanish and one kind of Turkish seeds). Within 24 hours all testing results became negative.


    Author Information:

    Ros, JJW
    Dutch Laboratory for Drugs and Doping, Hospital Pharmacy,

    Pelders, MG
    Dutch Laboratory for Drugs and Doping, Hospital Pharmacy,


    Stock #: JFS15415J

    ISSN: 0022-1198

    DOI: 10.1520/JFS15415J

    ASTM International
    is a member of CrossRef.

    Author
    Title Poppy Seeds: Differences in Morphine and Codeine Content and Variation in Inter- and Intra-Individual Excretion
    Symposium , 0000-00-00
    Committee E30