Volume 47, Issue 3 (May 2002)

    Fatal Meningitis and Encephalitis Due to Bartonella henselae Bacteria

    (Received 24 October 2001; accepted 15 October 2001)

    Published Online: May

    CODEN: JFSOAD

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    Abstract

    Bacterial infection due to Bartonella henselae commonly develops in children and young adults following cat/dog ontacts and/or cat/dog scratches. Regional lymphadenopathy is its most common clinical expression. However, encephalitis and Parinaud's syndrome (oculoglandular syndrome) have also been reported as has systemic illness. A review of the international literature in all languages revealed no fatal complications in immunocompetent hosts. A four-year-old white child with no underlying illness began to have seizure-like activity. She was taken to a local hospital and subsequently transferred to a medical center. The child was treated aggressively for seizures and fever of unknown origin. However, her condition rapidly declined and she died without a specific diagnosis. At autopsy there was marked cerebral edema with no gross evidence of acute meningitis. Microscopic exams revealed multiple granulomatous lesions as well as a meningitis and encephalitis. A variety of cultures and stains were negative for acid fast and fungal organisms. Warthin-Starry stains of involved tissue including brain and liver revealed pleomorphic rod shaped bacilli consistent with Bartonella henselae. Analysis of brain tissue with polymerase chain reaction (PCR) and Southern blot for the deoxyribonucleic acid (DNA) was definitive for DNA of Bartonella henselae bacteria.


    Author Information:

    Gerber, JE
    Forensic Medical, Nashville, TN

    Johnson, JE
    Vanderbilt University Medical Center, Nashville, TN

    Madhusudhan, KT
    University of Arkansas for Medical Sciences, Little Rock, AR

    Scott, MA
    University of Arkansas for Medical Sciences, Little Rock, AR


    Stock #: JFS15307J

    ISSN: 0022-1198

    DOI: 10.1520/JFS15307J

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    Author
    Title Fatal Meningitis and Encephalitis Due to Bartonella henselae Bacteria
    Symposium , 0000-00-00
    Committee E30