Online Y-chromosomal Short Tandem Repeat Haplotype Reference Database (YHRD) for U.S. Populations

    Volume 47, Issue 3 (May 2002)

    ISSN: 0022-1198

    CODEN: JFSOAD

    Published Online: 1 May 2001

    Page Count: 7


    Schädlich, H
    Max Planck Institute for Evolutionary Anthropology, Leipzig,

    Zawacki, J
    Office of Chief Medical Examiner, New York City, NY

    Roewer, L
    Institute for Legal Medicine, Humboldt-University Berlin, Berlin,

    Batzer, MA
    Louisiana State University, Baton Rouge, LA

    Kayser, M
    Max Planck Institute for Evolutionary Anthropology, Leipzig,

    Prinz, M
    Office of Chief Medical Examiner, New York City, NY

    Stoneking, M
    Max Planck Institute for Evolutionary Anthropology, Leipzig,

    Brauer, S
    Max Planck Institute for Evolutionary Anthropology, Leipzig,

    Willuweit, S
    Institute for Legal Medicine, Humboldt-University Berlin, Berlin,

    (Received 1 November 2001; accepted 18 October 2001)

    Abstract

    We describe here an online Y-chromosomal short tandem repeat haplotype reference database (YHRD) for U.S. populations, which represents 9-locus Y-STR haplotypes for 1705 African-Americans, European-Americans and Hispanics as of October 2001. This database is available online (http://www.ystr. org/usa/), free to access and was generated in order to supply the U.S. forensic DNA community with a valuable resource for frequencies of complete or incomplete 9-locus Y-STR haplotypes, as well as information about typing protocols and population genetic analyses. Pairwise RST-statistics derived from the Y-STR haplotypes indicate no significant substructure among African-American populations from different regions of the U.S., nor (usually) among European-American and Hispanic populations. Thus, pooling of YSTR haplotype data from regional populations within these three major groups is appropriate in order to obtain larger sample sizes. However, pooling of different major populations is generally not recommended due to statistically significant differences between African-American populations and all European-American / Hispanic populations, as well as between some European-American and Hispanic populations.


    Paper ID: JFS15290J

    DOI: 10.1520/JFS15290J

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    Author
    Title Online Y-chromosomal Short Tandem Repeat Haplotype Reference Database (YHRD) for U.S. Populations
    Symposium , 0000-00-00
    Committee E30