(Received 12 January 2000; accepted 26 February 2001)
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There are no published reports that include both timely antemortem and postmortem carbamazepine concentrations after massive overdose. We report a fatal overdose of carbamazepine with both timely antemortem and postmortem carbamazepine concentrations. Carbamazepine concentrations were 47.7 mcg/mL 2 h antemortem and 53 mcg/mL at 9 h postmortem. The slight rise in drug concentration may reflect continued absorption of the drug in the last 2 h before death. Postmortem carbamazepine concentrations drawn from a peripheral vessel in this patient appeared to reflect drug concentrations at the time of death.
Kentucky Regional Poison Center of Kosair Children's Hospital, Louisville, KY
Hardin Memorial Hospital, Elizabethtown, KY
Stock #: JFS15182J