Timely Antemortem and Postmortem Concentrations in a Fatal Carbamazepine Overdose

    Volume 46, Issue 6 (November 2001)

    ISSN: 0022-1198

    CODEN: JFSOAD

    Page Count: 3


    Spiller, HA
    Kentucky Regional Poison Center of Kosair Children's Hospital, Louisville, KY

    Carlisle, RD
    Hardin Memorial Hospital, Elizabethtown, KY

    (Received 12 January 2000; accepted 26 February 2001)

    Abstract

    There are no published reports that include both timely antemortem and postmortem carbamazepine concentrations after massive overdose. We report a fatal overdose of carbamazepine with both timely antemortem and postmortem carbamazepine concentrations. Carbamazepine concentrations were 47.7 mcg/mL 2 h antemortem and 53 mcg/mL at 9 h postmortem. The slight rise in drug concentration may reflect continued absorption of the drug in the last 2 h before death. Postmortem carbamazepine concentrations drawn from a peripheral vessel in this patient appeared to reflect drug concentrations at the time of death.


    Paper ID: JFS15182J

    DOI: 10.1520/JFS15182J

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    Title Timely Antemortem and Postmortem Concentrations in a Fatal Carbamazepine Overdose
    Symposium , 0000-00-00
    Committee E30