Length Variation in HV2 of the Human Mitochondrial DNA Control Region

    Volume 46, Issue 4 (July 2001)

    ISSN: 0022-1198

    CODEN: JFSOAD

    Page Count: 9


    Isenberg, AR
    DNA Analysis Unit II, FBI Laboratory, Washington, D.C.

    Budowle, B
    Senior scientist, FBI Laboratory, Washington, D.C.

    Fisher, CL
    DNA Analysis Unit II, FBI Laboratory, Washington, D.C.

    Polanskey, D
    DNA Analysis Unit II, FBI Laboratory, Washington, D.C.

    Pokorak, E
    DNA Analysis Unit II, FBI Laboratory, Washington, D.C.

    DiZinno, JA
    DNA Analysis Unit II, FBI Laboratory, Washington, D.C.

    Stewart, JEB
    DNA Analysis Unit II, FBI Laboratory, Washington, D.C.

    Wilson, MR
    DNA Analysis Unit II, FBI Laboratory, Washington, D.C.

    Aagaard, PJ
    DNA Analysis Unit II, FBI Laboratory, Washington, D.C.

    (Received 23 September 1999; accepted 11 September 2000)

    Abstract

    Hair samples were typed from three individuals who exhibited length heteroplasmy in the homopolymeric cytosine stretches (C-stretch) in hypervariable region 2 (HV2). The study demonstrated that for different hairs within an individual, the HV2 C-stretch region can vary with respect to the number of cytosines and/or proportion of C-stretch length variants. Length heteroplasmy may occur regardless of the prominent length variant present in this region. Differences in the number of cytosines at the C-stretch region, or a variation in the relative amounts of heteroplasmic length variants, cannot be used to support an interpretation of exclusion.


    Paper ID: JFS15059J

    DOI: 10.1520/JFS15059J

    ASTM International
    is a member of CrossRef.

    Author
    Title Length Variation in HV2 of the Human Mitochondrial DNA Control Region
    Symposium , 0000-00-00
    Committee E30