Neuropathological Findings Associated with Retained Lead Shot Pellets in a Man Surviving Two Months After a Suicide Attempt

    Volume 46, Issue 3 (May 2001)

    ISSN: 0022-1198

    CODEN: JFSOAD

    Page Count: 5


    Malandrini, A
    Laboratory of Neuropathology, Institute of Neurological Sciences, University of Siena, Siena,

    Salvadori, C
    Laboratory of Neuropathology, Institute of Neurological Sciences, University of Siena, Siena,

    Berti, G
    Laboratory of Neuropathology, Institute of Neurological Sciences, University of Siena, Siena,

    Di Paolo, M
    Institute of Legal Medicine, University of Siena, Siena,

    Villanova, M
    Laboratory of Neuromuscular Pathology, Rizzoli Hospital, Bologna,

    Gambelli, S
    Laboratory of Neuropathology, Institute of Neurological Sciences, University of Siena, Siena,

    (Received 3 December 1999; accepted 5 June 2000)

    Abstract

    We describe the neuropathological findings in a 30-year-old man who died two months after attempting suicide with a shotgun. We focused our study on lesions associated with retained lead shot pellets and distant therefrom, as well as lesions distant from the principal site of injury. At the sites of the retained lead shot pellets, we found macrophage proliferation and astrocyte activation, together with axonal spheroids and signs of neuronal damage. In the remaining white matter we observed axonal swellings, astrocyte activation and rarefaction of the neuropil; regressive phenomena of the neurons were also present. All axonal spheroids immunoreacted with antibodies against APP. αB-crystallin, NF subunits and ubiquitin. Most reactive astrocytes were positive for GFAP and αB-crystallin immunostaining. Some neurons immunoreacting with αB-crystallin were also found. These data indicated that an important local reaction developed at the sites of lead shot retention, and mild signs of diffuse axonal damage were found throughout the brain.


    Paper ID: JFS15029J

    DOI: 10.1520/JFS15029J

    ASTM International
    is a member of CrossRef.

    Author
    Title Neuropathological Findings Associated with Retained Lead Shot Pellets in a Man Surviving Two Months After a Suicide Attempt
    Symposium , 0000-00-00
    Committee E30