Journal Published Online: 01 March 2001
Volume 46, Issue 2

Identifying Sex Chromosome Abnormalities in Forensic DNA Testing Using Amelogenin and Sex Chromosome Short Tandem Repeats

CODEN: JFSCAS

Abstract

Forensic DNA laboratories worldwide have begun using multiplexed STR systems to decrease analysis time and increase sample throughput. The loci used in these systems are basically “nonsense” regions of human DNA. However, due to the chromosome on which some of these loci are located, various genetic abnormalities can sometimes be detected. This paper will show one such abnormality—Klinefelter's Syndrome—and the process used to show the possibility of this defect in two undiagnosed males using peak height ratios at the Amelogenin locus, and X-Y STRs.

Author Information

Young, DR
Texas Department of Public Safety Crime Laboratory, Lubbock, Texas
Tun, Z
Osaka University Graduate School of Medicine, Osaka, Japan
Honda, K
Osaka University Graduate School of Medicine, Osaka, Japan
Matoba, R
Osaka University Graduate School of Medicine, Osaka, Japan
Pages: 3
Price: $25.00
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Stock #: JFS14969J
ISSN: 0022-1198
DOI: 10.1520/JFS14969J