North Carolina State University, Raleigh, NC
Toronto General Hospital, Toronto,
Centre of Excellence in Molecular Biology, Lahore,
A population genetic characterization of the Araeen and Raajpoot ethnic subpopulations of Lahore City, Pakistan was undertaken in order to assess the utility of DNA typing for forensic purposes in Pakistani populations. One hundred unrelated individuals from each group were genotyped for four independently assorting loci: HLA DQA1, CSF1PO, TPOX, and TH01. Allele frequencies were calculated, one- and two-locus tests for association were conducted, and the samples were compared by contingency table tests and F-statistic estimation. Although there is expected to be some genetic divergence between the two groups, forensic needs may be satisfied with a single Pakistani database of DNA profiles. The present data suggest that nine independently assorting loci will be sufficient to provide estimated profile probabilities of the order of 10−9 but a set of 13 loci, as employed in the U.S., would better compensate for the dependencies introduced by family membership and evolutionary history.
Paper ID: JFS14920J