Volume 45, Issue 5 (September 2000)

    Regional Distribution of Cocaine in Postmortem Brain of Chronic Human Cocaine Users

    (Received 14 September 1999; accepted 29 October 1999)

    CODEN: JFSOAD

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    Abstract

    We measured concentrations of cocaine and its major metabolites (benzoylecgonine, ecgonine methylester, norcocaine, and cocaethylene) in 15 autopsied brain regions of 14 human chronic cocaine users. Only slight differences were observed in concentrations of cocaine and its metabolites amongst the examined brain areas. Although it is likely that some postmortem redistribution of the drug must have occurred, our data are consistent with the possibility that behaviorally relevant doses of cocaine are widely distributed throughout the brain of humans who use the drug on a chronic basis. Consideration should therefore be given to the possible pharmacological and toxicological actions of cocaine in both striatal and extra-striatal brain areas in human users of the drug.


    Author Information:

    Schmunk, GA
    Santa Clara County Medical Examiner-Coroner, San Jose, CA and Stanford University, Palo Alto, CA

    Smialek, J
    University of Maryland, Baltimore, MD

    Kalasinsky, KS
    Division of Forensic Toxicology, Office of the Armed Forces Medical Examiner, Division of Forensic Toxicology, Armed Forces Institute of Pathology, Washington, DC

    Ang, L
    Department of Pathology (Neuropathology), Sunnybrook Hospital, Toronto,

    Guttman, M
    Human Neurochemical Pathology Laboratory, Centre for Addiction and Mental Health, Clarke Division, Toronto, Ontario

    Gore, SB
    Office of the Medical Examiner of District 9, Onando, FL

    Kish, SJ
    Human Neurochemical Pathology Laboratory, Centre for Addiction and Mental Health, Clarke Division, Toronto, Ontario

    Bosy, TZ
    Division of Forensic Toxicology, Office of the Armed Forces Medical Examiner, Division of Forensic Toxicology, Armed Forces Institute of Pathology, Washington, DC

    Adams, V
    Office of the Hillsborough County Medical Examiner, Tampa, FL

    Furukawa, Y
    Human Neurochemical Pathology Laboratory, Centre for Addiction and Mental Health, Clarke Division, Toronto, Ontario


    Stock #: JFS14828J

    ISSN: 0022-1198

    DOI: 10.1520/JFS14828J

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    Author
    Title Regional Distribution of Cocaine in Postmortem Brain of Chronic Human Cocaine Users
    Symposium , 0000-00-00
    Committee E30