Volume 45, Issue 3 (May 2000)

    The Comparison of Toluene Determination Between Headspace-Solid Phase Microextraction and Headspace Methods in Glue-Sniffer's Blood and Urine Samples

    (Received 4 May 1999; accepted 27 July 1999)

    CODEN: JFSOAD

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    Abstract

    An accurate and simple method was developed to determine the level of toluene in urine and blood quantitatively by using the gas chromatography/mass spectrometry (GC/MS) with headspace—solid phase microextraction (HS-SPME) technique. An assembly of SPME with a replaceable extraction fiber, coated with 100 μm polydimethylsiloxane, was used. The detection limit of toluene in blood and urine with HS-SPME technique was 10 times higher than that with headspace (HS) technique. To compare the HS-SPME with HS technique for the determination of toluene in biological fluids, blood and urine samples from glue sniffers were analyzed by both methods. The level of toluene by the two techniques was highly correlated: the correlation coefficient (r2) between the two sets of values were 0.98 and 0.96 in urine and blood, respectively.


    Author Information:

    Kim, NY
    National Institute of Scientific Investigation, Seoul,

    Park, SW
    National Institute of Scientific Investigation, Seoul,


    Stock #: JFS14754J

    ISSN: 0022-1198

    DOI: 10.1520/JFS14754J

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    Author
    Title The Comparison of Toluene Determination Between Headspace-Solid Phase Microextraction and Headspace Methods in Glue-Sniffer's Blood and Urine Samples
    Symposium , 0000-00-00
    Committee E30