ISSN: 0022-1198
CODEN: JFSCA
Page Count: 6

The Comparison of Toluene Determination Between Headspace-Solid Phase Microextraction and Headspace Methods in Glue-Sniffer's Blood and Urine Samples
Kim, NY
National Institute of Scientific Investigation,

Park, SW
National Institute of Scientific Investigation,

(Received 4 May 1999; accepted 27 July 1999)

Abstract

An accurate and simple method was developed to determine the level of toluene in urine and blood quantitatively by using the gas chromatography/mass spectrometry (GC/MS) with headspace—solid phase microextraction (HS-SPME) technique. An assembly of SPME with a replaceable extraction fiber, coated with 100 μm polydimethylsiloxane, was used. The detection limit of toluene in blood and urine with HS-SPME technique was 10 times higher than that with headspace (HS) technique. To compare the HS-SPME with HS technique for the determination of toluene in biological fluids, blood and urine samples from glue sniffers were analyzed by both methods. The level of toluene by the two techniques was highly correlated: the correlation coefficient (r²) between the two sets of values were 0.98 and 0.96 in urine and blood, respectively.

Keywords:
forensic science, toluene, inhalant abuse, glue-sniffing, headspace-solid phase microextraction

Paper ID: JFS14754J
DOI: 10.1520/JFS14754J
ASTM International is a member of CrossRef.