The Comparison of Toluene Determination Between Headspace-Solid Phase Microextraction and Headspace Methods in Glue-Sniffer's Blood and Urine Samples

    Volume 45, Issue 3 (May 2000)

    ISSN: 0022-1198

    CODEN: JFSOAD

    Page Count: 6


    Kim, NY
    National Institute of Scientific Investigation, Seoul,

    Park, SW
    National Institute of Scientific Investigation, Seoul,

    (Received 4 May 1999; accepted 27 July 1999)

    Abstract

    An accurate and simple method was developed to determine the level of toluene in urine and blood quantitatively by using the gas chromatography/mass spectrometry (GC/MS) with headspace—solid phase microextraction (HS-SPME) technique. An assembly of SPME with a replaceable extraction fiber, coated with 100 μm polydimethylsiloxane, was used. The detection limit of toluene in blood and urine with HS-SPME technique was 10 times higher than that with headspace (HS) technique. To compare the HS-SPME with HS technique for the determination of toluene in biological fluids, blood and urine samples from glue sniffers were analyzed by both methods. The level of toluene by the two techniques was highly correlated: the correlation coefficient (r2) between the two sets of values were 0.98 and 0.96 in urine and blood, respectively.


    Paper ID: JFS14754J

    DOI: 10.1520/JFS14754J

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    Title The Comparison of Toluene Determination Between Headspace-Solid Phase Microextraction and Headspace Methods in Glue-Sniffer's Blood and Urine Samples
    Symposium , 0000-00-00
    Committee E30