Volume 45, Issue 1 (January 2000)

    Allelic Frequencies for the HLA-DQA1, D1S80, HUMTHO1, HUMTPOX, HUMCSF1PO and HUMVWA Loci in Cantabria (Middle North Spain)

    (Received 8 February 1999; accepted 1 June 1999)

    CODEN: JFSOAD

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    Abstract

    Allele frequencies for six DNA polymorphisms have been studied in a population sample from Cantabria (middle north Spain) using the polymerase chain reaction. The HLA-DQA1 locus was analyzed by the reverse dot-blot technique and the other five by polyacrylamide gel electrophoresis followed by silver staining. Six alleles were found for HLA-DQA1, 15 alleles for D1S80, 6 alleles for HUMTHO1 and HUMCSF1PO, 7 for HUMTPOX and 8 alleles for HUMVWA. The 21 repeat allele in HUMVWA had not previously been reported in a Spanish population. The genotype distributions met Hardy-Weinberg expectations for all the systems and some statistical parameters of forensic interest were calculated. Comparisons with other populations revealed significant differences for HLA-DQA1, HUMVWA and HUMTHO1, with interracial differences being more pronounced than between Spanish populations. The HUMVWA system showed the highest forensic efficiency of the six polymorphisms studied.


    Author Information:

    Sánchez-Molina, I
    Unit of Legal Medicine, University of Cantabria,

    Calvet, R
    Unit of Legal Medicine, University of Cantabria,


    Stock #: JFS14653J

    ISSN: 0022-1198

    DOI: 10.1520/JFS14653J

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    Title Allelic Frequencies for the HLA-DQA1, D1S80, HUMTHO1, HUMTPOX, HUMCSF1PO and HUMVWA Loci in Cantabria (Middle North Spain)
    Symposium , 0000-00-00
    Committee E30