Iliac Cancellous Bone in Drug Addicts: A Histomorphometric Study

    Volume 44, Issue 2 (March 1999)

    ISSN: 0022-1198

    CODEN: JFSOAD

    Page Count: 4


    Schiwy-Bochat, K-H
    Institute of Forensic Medicine, Aachen University of Technology, Aachen,

    Lemke, R
    Institute of Forensic Medicine, Aachen University of Technology, Aachen,

    (Received 23 March 1998; accepted 5 August 1998)

    Abstract

    Histomorphometry was used to determine structural bone changes in drug addicts. Iliac crest bone biopsies were obtained at autopsy from 28 subjects (21 male, 7 female, aged 18 to 45 years) who had a history of drug abuse and had died due to overdose of illicit drugs. For histomorphometry, undecalcified sections were investigated using the Merz grid. The following histomorphometric indices were measured and calculated: BV/TV, BS/BV, Tb.Th, Tb.N, Tb.Sp, OV/TV, OS/BS, Ob.S/BS, O.Th, ES/BS, Oc.S/BS, and N.Oc/T.A. In 28 controls (24 male, 4 female, aged 17 to 47 years) trabecular bone specimens were investigated in the same way. The parameters in drug addicts did not show any correlation to age, body weight, height or sex differences. Trabecular bone volume and trabecular thickness were slightly but not significantly increased (BV/TV: 23.37 ± 5.77% (mean, SD), controls 22.23 ± 5.08%, p = 0.434; Tb.Th: 172.67 ± 36.83 mcm, controls 169.73 ± 36.13 mcm, p = 0.764). Only the eroded surface was significantly different to the controls (ES/BS: 8.16 ± 2.04%, controls 6.96 ± 2.17%, p = 0.038). We conclude that the incidence of metabolic bone disease in drug addicts is low.


    Paper ID: JFS14448J

    DOI: 10.1520/JFS14448J

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    Title Iliac Cancellous Bone in Drug Addicts: A Histomorphometric Study
    Symposium , 0000-00-00
    Committee E30