Volume 44, Issue 1 (January 1999)

    A Study Involving Venlafaxine Overdoses: Comparison of Fatal and Therapeutic Concentrations in Postmortem Specimens

    (Received 13 April 1998; accepted 11 May 1998)

    CODEN: JFSOAD

      Format Pages Price  
    PDF 4 $25   ADD TO CART


    Abstract

    The distribution and redistribution of venlafaxine were investigated in two overdoses and several cases involving the therapeutic use of venlafaxine. Blood, liver, bile vitreous humor, urine and gastric contents were analyzed using high performance liquid chromatography with ultraviolet detection. Blood concentrations of venlafaxine in the two overdose cases were 53 mg/L and 78 mg/L. Comparison of venlafaxine concentrations in blood samples taken at different times after death revealed increases in concentrations over time, suggesting the possible postmortem redistribution of venlafaxine.


    Author Information:

    DeSilva, D
    MRC.Path, FRC.Path, Pathologist, Mildura Base Hospital, Barratt & Smith Pathology, Mildura, Victoria

    Batziris, HP
    Victorian Institute of Forensic Medicine and Department of Forensic Medicine, Monash University, Melbourne, Victoria

    McIntyre, IM

    Hoeven, P van der
    PRCPC, FRCPA, Pathologist, Gippsland Pathology Service, Traralgon, Victoria

    Jaffe, PD
    Victorian Institute of Forensic Medicine and Department of Forensic Medicine, Monash University, Melbourne, Victoria


    Stock #: JFS14434J

    ISSN: 0022-1198

    DOI: 10.1520/JFS14434J

    ASTM International
    is a member of CrossRef.

    Author
    Title A Study Involving Venlafaxine Overdoses: Comparison of Fatal and Therapeutic Concentrations in Postmortem Specimens
    Symposium , 0000-00-00
    Committee E30