HLA-DQA1 and Polymarker Allele Frequencies in Two New York City Jewish Populations

    Volume 42, Issue 5 (September 1997)

    ISSN: 0022-1198

    CODEN: JFSOAD

    Page Count: 4


    Eng, CM
    Mt. Sinai School of Medicine, City University of New York, NY

    Kingston, C
    John Jay College of Criminal Justice City University of New York, New York, NY

    Medintz, I
    Graduate School and University Center, City University of New York, NY

    Chiriboga, L
    Graduate School and University Center, City University of New York, NY

    Kobilinsky, L

    Levine, L
    City College, City University of New York, NY

    McCurdy, L
    Mt. Sinai School of Medicine, City University of New York, NY

    Desnick, RJ
    Mt. Sinai School of Medicine, City University of New York, NY

    (Received 7 August 1996; accepted 24 January 1997)

    Abstract

    Allele and genotype frequencies were determined for the HLA-DQA1 and Amplitype® Polymarker loci (low density lipoprotein receptor (LDLR), glycophorin A (GYPA), hemoglobin G gammaglobin (HBGG), D7S8, and group-specific component (Gc)) in Hasidic and non-Hasidic Ashkenazi New York City Jewish subpopulations. For all loci tested, except HBGG, the 2 subpopulations meet the assumption of Hardy-Weinberg equilibrium. Comparison of various allele and genotype frequencies for the Hasidic and the non-Hasidic groups showed no significant differences. Comparison of the various allele frequencies in the two subpopulations to another Caucasian group revealed significant differences at the HLA-DQA1 and D7S8 loci in the Hasidic group. These frequency data can be used for comparison to other populations and for frequency estimates in DNA profiling.


    Paper ID: JFS14231J

    DOI: 10.1520/JFS14231J

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    Author
    Title HLA-DQA1 and Polymarker Allele Frequencies in Two New York City Jewish Populations
    Symposium , 0000-00-00
    Committee E30