ISSN: 0022-1198
CODEN: JFSCA
Page Count: 4

HLA-DQA1 and Polymarker Allele Frequencies in Two New York City Jewish Populations
Eng, CM
Mt. Sinai School of Medicine, City University of New York, NY

Kingston, C
John Jay College of Criminal Justice City University of New York, NY

Medintz, I
Graduate School and University Center, City University of New York, NY

Chiriboga, L
Graduate School and University Center, City University of New York, NY

Kobilinsky, L

Levine, L
City College, City University of New York, NY

McCurdy, L
Mt. Sinai School of Medicine, City University of New York, NY

Desnick, RJ
Mt. Sinai School of Medicine, City University of New York, NY

(Received 7 August 1996; accepted 24 January 1997)

Abstract

Allele and genotype frequencies were determined for the HLA-DQA1 and Amplitype® Polymarker loci (low density lipoprotein receptor (LDLR), glycophorin A (GYPA), hemoglobin G gammaglobin (HBGG), D7S8, and group-specific component (Gc)) in Hasidic and non-Hasidic Ashkenazi New York City Jewish subpopulations. For all loci tested, except HBGG, the 2 subpopulations meet the assumption of Hardy-Weinberg equilibrium. Comparison of various allele and genotype frequencies for the Hasidic and the non-Hasidic groups showed no significant differences. Comparison of the various allele frequencies in the two subpopulations to another Caucasian group revealed significant differences at the HLA-DQA1 and D7S8 loci in the Hasidic group. These frequency data can be used for comparison to other populations and for frequency estimates in DNA profiling.

Keywords:
forensic science, DNA typing, Jewish populations, New York City, HLA-DQA1, polymarker, LDLR, GYPA, HBGG, D7S8, GC, population genetics, allele frequencies, polymerase chain reaction

Paper ID: JFS14231J
DOI: 10.1520/JFS14231J
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