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    Volume 41, Issue 6 (November 1996)

    A Fatal Case of Methotrimeprazine Overdose

    (Received 16 November 1995; accepted 8 March 1996)


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    Fatal ingestion of methotrimeprazine is unusual, and while therapeutic drug levels are established as concentrations between 0.02 to 0.14 mg/L, fatal levels are not. The following describes a case of fatal suicidal ingestion of methotrimeprazine in which the measured concentration of methotrimeprazine in the blood was 4.1 mg/L. In addition, the major metabolites of methotrimeprazine, desmethylmethotrimeprazine, and methotrimeprazine sulfoxide were also measured at 2.0 and 1.8 mg/L, respectively. Methotrimeprazine and its metabolites were also measured in urine, bile, and vitreous humor. These results are compared with other case reports of methotrimeprazine fatalities reported in the literature.

    Author Information:

    Holzbecher, MD
    Forensic toxicologist, RCMP Forensic Laboratory, Halifax N.S.,

    Avis, SP
    Chief forensic pathologist, Province of Newfoundland and Labrador, Health Sciences Center, St. John's, Newfoundland

    Stock #: JFS14055J

    ISSN: 0022-1198

    DOI: 10.1520/JFS14055J

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    Title A Fatal Case of Methotrimeprazine Overdose
    Symposium , 0000-00-00
    Committee E30