Extent of Heterogeneity in Mitochondrial DNA of Ethnic Asian Populations

    Volume 41, Issue 4 (July 1996)

    ISSN: 0022-1198

    CODEN: JFSOAD

    Page Count: 12


    Stoneking, M
    The Pennsylvania State University, University Park, PA

    Melton, T
    The Pennsylvania State University, University Park, PA

    (Received 14 August 1995; accepted 22 December 1995)

    Abstract

    Variation in the mitochondrial DNA (mtDNA) control region as detected by sequence-specific oligonucleotide (SSO) probes is described for 993 individuals in 11 ethnic Asian populations. Estimates of diversity for mtDNA types exceed 0.94 in all populations, while 53% of the 255 types that were observed occur only once. Of 96 shared types, four occur at frequencies of greater than 10% but less than 17% in any one population. There is statistically significant heterogeneity among these 11 populations, however, an analysis of variance incorporating genetic distances between types shows that at least 95% of the variation present in the total sample is attributable to within-population diversity, while only 5% is due to between-population differences. Overall, heterogeneity with respect to mtDNA SSO types is grossly correlated with geographic distance between populations; the most extreme heterogeneity was observed between populations from East Asia and populations from West Asia. With respect to population genetics, the control region of mtDNA exhibits satisfactory qualities as a DNA typing locus.


    Paper ID: JFS13960J

    DOI: 10.1520/JFS13960J

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    Author
    Title Extent of Heterogeneity in Mitochondrial DNA of Ethnic Asian Populations
    Symposium , 0000-00-00
    Committee E30