Histological Criteria for Diagnosis of Amanita Phalloides Poisoning

    Volume 41, Issue 3 (May 1996)

    ISSN: 0022-1198

    CODEN: JFSOAD

    Page Count: 4


    Centini, F
    Assistant Professor, Medical Doctor, and Associate Professor, University of Siena, Policlinico Le Scotte, Siena,

    Di Paolo, M
    Assistant Professor, Medical Doctor, and Associate Professor, University of Siena, Policlinico Le Scotte, Siena,

    Fineschi, V
    Assistant Professor, Medical Doctor, and Associate Professor, University of Siena, Policlinico Le Scotte, Siena,

    (Received 21 March 1995; accepted 16 October 1995)

    Abstract

    Five fatal cases of poisoning from ingestion of Amanita phalloides, a very common mushroom in central Italy, are reported. The fact that four of the cases occurred simultaneously enabled uniform collection of clinical, pathology and toxicology data, which is presented with particular emphasis on the histological aspects. The fifth case involved a six-year-old girl, and is discussed with reference to differential diagnosis with respect to Reye's syndrome, which was the initial diagnosis, demonstrated incorrect by the histology, pathology and toxicology findings.

    The typical liver and kidney alterations of Amanita phalloides poisoning, consisting of massive hepatic central lobular cell necrosis and acute tubular necrosis of the kidney are described. Outside the liver, there was often general hemorrhagic diathesis and severe brain edema.

    Although poisoning by Amanita phalloides is rare, these cases confirm the requirement for as complete a comparison as possible between circumstantial histopathological and toxicological data for the purposes of forensic diagnosis.


    Paper ID: JFS13929J

    DOI: 10.1520/JFS13929J

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    Title Histological Criteria for Diagnosis of Amanita Phalloides Poisoning
    Symposium , 0000-00-00
    Committee E30