Volume 40, Issue 6 (November 1995)

    Methamphetamine and Amphetamine Derived from the Metabolism of Selegiline

    (Received 24 January 1995; accepted 13 April 1995)

    CODEN: JFSOAD

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    Abstract

    Routine methamphetamine testing identified a urine specimen with inconsistent screening and confirmation results. The methamphetamine RIA screening test (Diagnostic Products Corporation) indicated a borderline positive specimen, while the achiral confirmatory GC/MS result showed 4690 ng/mL of methamphetamine and 1895 ng/mL of amphetamine. Analysis of the specimen after derivatization with S(-)-N-trifluoroacetylprolyl chloride showed only the presence of 1-amphetamine and 1-methamphet-amine. It was later learned that the individual providing the specimen had been taking Selegiline.

    Selegiline, (-) propynylmethamphetamine, is a monoamine oxidase inhibitor used for the treatment of Parkinson's disease. It is sold under the trade name Eldepryl. Its major metabolites are 1-methamphetamine, 1-amphetamine and N-desmethylselegiline.

    Urine specimens from other Selegiline users were obtained and analyzed. A characteristic metabolic pattern was noted, exemplified by a ratio of 1-methamphetamine to 1-amphetamine of about 2.8. This is in contrast to what is observed in the urine of individuals who ingest pure 1-methamphetamine, such as with Vicks Inhaler, where the 1-methamphetamine to 1-amphetamine ratio in the urine is usually greater than 8. Caution is advised when interpreting methamphetamine results without using a chiral identification technique.


    Author Information:

    Greedan, A
    Quality Assurance Director, Director of Scientific Affairs, Production Supervisor, and Commanding Officer, Navy Drug Screening Laboratory, Great Lakes, IL

    Jacob Snyder, J
    Quality Assurance Director, Director of Scientific Affairs, Production Supervisor, and Commanding Officer, Navy Drug Screening Laboratory, Great Lakes, IL

    Romberg, RW
    Quality Assurance Director, Director of Scientific Affairs, Production Supervisor, and Commanding Officer, Navy Drug Screening Laboratory, Great Lakes, IL

    Needleman, SB
    Quality Assurance Director, Director of Scientific Affairs, Production Supervisor, and Commanding Officer, Navy Drug Screening Laboratory, Great Lakes, IL


    Stock #: JFS13885J

    ISSN: 0022-1198

    DOI: 10.1520/JFS13885J

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    Author
    Title Methamphetamine and Amphetamine Derived from the Metabolism of Selegiline
    Symposium , 0000-00-00
    Committee E30