A Comparative Study of Genetic Variation at Five VNTR Loci in Three Ethnic Groups of Houston, Texas

    Volume 40, Issue 6 (November 1995)

    ISSN: 0022-1198

    CODEN: JFSOAD

    Page Count: 10


    Sharma, BR
    Houston Police Department Crime Laboratory, Houston, TX

    Bolding, JR
    Houston Police Department Crime Laboratory, Houston, TX

    Jin, L
    Stanford University Medical School, Stanford, CA

    Thompson, M
    Houston Police Department Crime Laboratory, Houston, TX

    Chakraborty, R
    Center for Demographic and Population Genetics, University of Texas Health Science Center at Houston, Houston, TX

    Zhong, Y
    Center for Demographic and Population Genetics, University of Texas Health Science Center at Houston, Houston, TX

    (Received 12 September 1994; accepted 1 May 1995)

    Abstract

    Following the technique of Southern blot restriction fragment length polymorphisms (RFLP) analysis, we generated a database of DNA profiles at five Variable Number of Tandem Repeats loci (D1S7, D2S44, D4S139, D10S28, and D17S79) for 669 individuals of three major ethnic populations (Caucasians, Blacks, and Hispanics) of Houston, Texas. Analysis of fragment sizes at these loci within each sample, as well as their fixed-bin analyses, reveal that the assumptions of independence of allelic occurrences within and between loci are valid for this database. Fixed-bin allele frequency tables, therefore, are the best descriptors of this database for conservative forensic calculations. Finally, we demonstrate that this regional database from Houston, Texas, does not yield any meaningfully different forensic inference than the one obtained from the National database of the respective ethnic groups.


    Paper ID: JFS13860J

    DOI: 10.1520/JFS13860J

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    Title A Comparative Study of Genetic Variation at Five VNTR Loci in Three Ethnic Groups of Houston, Texas
    Symposium , 0000-00-00
    Committee E30