ISSN: 0022-1198
CODEN: JFSCA
Page Count: 10

Synthesis and Characterization of the 2,3-Methylenedioxyamphetamines
Casale, JF
Senior Forensic Chemists and Supervisory Chemist, U.S. Drug Enforcement Administration, Special Testing and Research Laboratory, VA

Hays, PA
Senior Forensic Chemists and Supervisory Chemist, U.S. Drug Enforcement Administration, Special Testing and Research Laboratory, VA

Klein, RFX
Senior Forensic Chemists and Supervisory Chemist, U.S. Drug Enforcement Administration, Special Testing and Research Laboratory, VA

(Received 25 July 1994; accepted 5 October 1994)

Abstract

Synthetic methods and spectroscopic and chromatographic data are provided for four 2,3-methylenedioxyamphetamines (2,3-MDA, N-methyl-2,3-MDA, N-ethyl-2,3-MDA and N,N-dimethyl-2,3-MDA). These compounds are aromatic positional isomers of the corresponding 3,4-methylenedioxyamphetamines, which are well known, widely abused central nervous system stimulants with euphoric properties. Direct spectroscopic and chromatographic comparisons of the two isomeric series indicate that the 2,3-MDA's may be easily and unambiguously differentiated from the corresponding 3,4-MDA's via standard analytical methodologies.

Keywords:
toxicology, 2,3-methylenedioxyamphetamine, analogs, positional isomers, designer drugs, synthesis, chemical analysis

Paper ID: JFS13793J
DOI: 10.1520/JFS13793J
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