Volume 40, Issue 1 (January 1995)

    Extraction of Psychotropic Drugs From Human Scalp Hair

    (Received 24 January 1994; accepted 10 June 1994)

    CODEN: JFSOAD

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    Abstract

    A comparison of techniques for the extraction of antidepressant and antipsychotic drugs in human scalp hair is described. Human scalp hair was obtained from cadavers known to be taking psychotropic drugs prior to their death. Following a washing step, hair was either solubilized in sodium hydroxide, or treated with dilute hydrochloric acid, methanol or subtilisin. Digests were treated with a solvent and the extracted drugs quantified by high performance liquid chromatography. The alkaline digestion procedure was found to be significantly more effective (P < 0.01) in recovering a range of antidepressant and antipsychotic drugs from hair than either the acidic, methanolic or enzymatic treatments.


    Author Information:

    Couper, FJ
    Honors Student, Chief Toxicologist, and Assistant Director (VIFP) and Honorary Associate Professor in Forensic Medicine, Victorian Institute of Forensic Pathology and Department of Forensic Medicine, Monash University, South Melbourne, Victoria

    McIntyre, IM
    Honors Student, Chief Toxicologist, and Assistant Director (VIFP) and Honorary Associate Professor in Forensic Medicine, Victorian Institute of Forensic Pathology and Department of Forensic Medicine, Monash University, South Melbourne, Victoria

    Drummer, OH
    Honors Student, Chief Toxicologist, and Assistant Director (VIFP) and Honorary Associate Professor in Forensic Medicine, Victorian Institute of Forensic Pathology and Department of Forensic Medicine, Monash University, South Melbourne, Victoria


    Stock #: JFS13765J

    ISSN: 0022-1198

    DOI: 10.1520/JFS13765J

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    Author
    Title Extraction of Psychotropic Drugs From Human Scalp Hair
    Symposium , 0000-00-00
    Committee E30