A Fatality Due to Flurazepam

    Volume 39, Issue 6 (November 1994)

    ISSN: 0022-1198

    CODEN: JFSOAD

    Page Count: 4


    Dow, CA
    Chief Scientist and Hon. Senior Research Fellow; Scientist-in-Charge; Scientist; Pathologist; Assistant Director and Hon. Associate Professor, Victorian Institute of Forensic Pathology, and Department of Forensic Medicine, Monash University, South Melbourne, Victoria

    McIntyre, IM
    Chief Scientist and Hon. Senior Research Fellow; Scientist-in-Charge; Scientist; Pathologist; Assistant Director and Hon. Associate Professor, Victorian Institute of Forensic Pathology, and Department of Forensic Medicine, Monash University, South Melbourne, Victoria

    Lawrence, KL
    Chief Scientist and Hon. Senior Research Fellow; Scientist-in-Charge; Scientist; Pathologist; Assistant Director and Hon. Associate Professor, Victorian Institute of Forensic Pathology, and Department of Forensic Medicine, Monash University, South Melbourne, Victoria

    Syrjanen, ML
    Chief Scientist and Hon. Senior Research Fellow; Scientist-in-Charge; Scientist; Pathologist; Assistant Director and Hon. Associate Professor, Victorian Institute of Forensic Pathology, and Department of Forensic Medicine, Monash University, South Melbourne, Victoria

    Drummer, OH
    Chief Scientist and Hon. Senior Research Fellow; Scientist-in-Charge; Scientist; Pathologist; Assistant Director and Hon. Associate Professor, Victorian Institute of Forensic Pathology, and Department of Forensic Medicine, Monash University, South Melbourne, Victoria

    (Received 31 January 1994; accepted 7 April 1994)

    Abstract

    A fatality attributed to suicidal ingestion of up to 2.2 grams of flurazepam is described. The deceased was a 52-year old female with a history of depression and suicidal attempts. No significant pathology was found at autopsy. Full toxicological analyses detected only flurazepam and metabolites in her tissues. The concentrations of flurazepam in femoral blood, liver, bile, vitreous humor and urine were 5.5 mg/L, 130 mg/kg, 33 mg/L, 1.3 mg/L and 3.3 mg/L, respectively. Analysis of gastric contents showed 600 mg of flurazepam. Desalkylflurazepam was also detected in blood, liver, bile and vitreous, but at much lower concentrations than the parent compound.


    Paper ID: JFS13746J

    DOI: 10.1520/JFS13746J

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    Author
    Title A Fatality Due to Flurazepam
    Symposium , 0000-00-00
    Committee E30