Detection and Determination of Pseudococaine in Coca Leaves and Illicit Cocaine Samples

    Volume 39, Issue 6 (November 1994)

    ISSN: 0022-1198

    CODEN: JFSOAD

    Page Count: 7


    Casale, JF
    U.S. Drug Enforcement Administration, Special Testing and Research Laboratory, McLean, VA

    Moore, JM
    U.S. Drug Enforcement Administration, Special Testing and Research Laboratory, McLean, VA

    (Received 28 February 1994; accepted 16 May 1994)

    Abstract

    Methodology is presented for the isolation, identification and determination of pseudococaine in coca leaves and illicit cocaine. Coca leaves, crude cocaine base (coca paste), refined cocaine base and refined cocaine hydrochloride, all derived from the same geographic location in Bolivia, were examined. Pseudococaine and other coca alkaloids were isolated from leaf samples using toluene extraction followed by acid/Celite trap and ion-pair column chromatography, and from crude and refined cocaine samples by acid/Celite column ion-pairing chromatography. Mass spectral analysis of coca leaf isolates confirmed the presence of pseudococaine. Pseudococaine was quantified by capillary gas chromatography with flame ionization detection at levels of 0.0001–0.035% (relative to cocaine) in refined illicit cocaine and coca leaves.


    Paper ID: JFS13741J

    DOI: 10.1520/JFS13741J

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    Author
    Title Detection and Determination of Pseudococaine in Coca Leaves and Illicit Cocaine Samples
    Symposium , 0000-00-00
    Committee E30