Assessing Ethnicity from Human Mitochondrial DNA Types Determined by Hybridization with Sequence-Specific Oligonucleotides

    Volume 39, Issue 6 (November 1994)

    ISSN: 0022-1198

    CODEN: JFSOAD

    Page Count: 12


    Connor, A
    Postdoctoral Associate, Population Research Institute, The Pennsylvania State University, University Park, Pennsylvania

    Stoneking, M
    Assistant Professor, The Pennsylvania State University, University Park, PA

    (Received 20 October 1993; accepted 25 April 1994)

    Abstract

    A logistic regression model was developed to predict ethnic group from mitochondrial DNA (mtDNA) types determined by hybridization with sequence-specific oligonucleotide (SSO) probes of the two hypervariable segments of the mtDNA control region. The model was developed with, and tested against, a previously reported data set of 525 individuals from five ethnic groups (African-American, Southeast Asian, Caucasian, Japanese, and Mexican) involving 23 probes at nine regions within the two hypervariable segments [1]. The model correctly predicted the ethnic group of 65.3% of the overall sample; however, the success rate varied substantially among ethnic groups, with the most success obtained with Caucasians (81% correctly classified). A discriminant analysis yielded similar results. An example is given of using the model to predict the ethnic group of an SSO-type from a forensic case. Such models provide alternatives to traditional skeletal-based methods of predicting ethnicity, especially in cases where skeletal material is absent or incomplete.


    Paper ID: JFS13725J

    DOI: 10.1520/JFS13725J

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    Title Assessing Ethnicity from Human Mitochondrial DNA Types Determined by Hybridization with Sequence-Specific Oligonucleotides
    Symposium , 0000-00-00
    Committee E30