An Experimental Methodology for the Study of Postmortem Changes in Toxic Concentrations of Drugs, Using Secobarbital As an Example

    Volume 39, Issue 5 (September 1994)

    ISSN: 0022-1198

    CODEN: JFSOAD

    Page Count: 5


    Ollier, A
    Forensic Physician, Pharmacologist, Forensic Physician, and Professor of Forensic Medicine, Laboratoire de Medecine Legale, Faculté de Medecine, Nice Cédex 2,

    Bourret, F
    Forensic Physician, Pharmacologist, Forensic Physician, and Professor of Forensic Medicine, Laboratoire de Medecine Legale, Faculté de Medecine, Nice Cédex 2,

    Quatrehomme, G
    Forensic Physician, Pharmacologist, Forensic Physician, and Professor of Forensic Medicine, Laboratoire de Medecine Legale, Faculté de Medecine, Nice Cédex 2,

    Liao, Z
    Forensic Physician, Pharmacologist, Forensic Physician, and Professor of Forensic Medicine, Laboratoire de Medecine Legale, Faculté de Medecine, Nice Cédex 2,

    (Received 4 October 1993; accepted 27 January 1994)

    Abstract

    Postmortem changes in alcohol and drug concentrations are well known today. The authors used an HPLC assay of barbiturates in postmortem tissue, and developed a rat model in order to evidence postmortem changes in toxics concentrations. Postmortem changes in secobarbital concentrations were evidenced using a rat-secobarbital model. This work emphasizes the difficulty of postmortem toxicology, as concentrations found at the time of autopsy may be different from concentrations at the time of death.


    Paper ID: JFS13716J

    DOI: 10.1520/JFS13716J

    ASTM International
    is a member of CrossRef.

    Author
    Title An Experimental Methodology for the Study of Postmortem Changes in Toxic Concentrations of Drugs, Using Secobarbital As an Example
    Symposium , 0000-00-00
    Committee E30