Volume 39, Issue 4 (July 1994)

    Nuclear Magnetic Resonance Identification of the Phenylalkylamine Alkaloids of Khat Using a Chiral Solvating Agent

    CODEN: JFSOAD

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    Abstract

    Nuclear magnetic resonance was used for the identification of three major alkaloids in dried leaves of the khat plant, Catha edulis. Proton nuclear magnetic resonance spectra of plant extracts confirmed the presence of cathinone, norpseudoephedrine and norephedrine. The subsequent addition of a chiral solvating agent, (S)-(−)-1,1′-bi-2-naphthol, to these NMR solutions enabled the identification of the various enantiomers of these alkaloids. Both the (S)- and (R)- enantiomers of cathinone were detected. The results from the determination of the alkaloid ratios in the dried plant material by the NMR method are compared to those obtained by a previously developed gas chromatographic method.


    Author Information:

    Lavoie, A
    Research Scientist, Research Technologist, Undergraduate Student and Research Scientist, Pharmaceutical Chemistry Division, Bureau of Drug Research, Health Protection Branch, Ottawa, Ontario

    Dawson, BA
    Research Scientist, Research Technologist, Undergraduate Student and Research Scientist, Pharmaceutical Chemistry Division, Bureau of Drug Research, Health Protection Branch, Ottawa, Ontario

    Black, DB
    Research Scientist, Research Technologist, Undergraduate Student and Research Scientist, Pharmaceutical Chemistry Division, Bureau of Drug Research, Health Protection Branch, Ottawa, Ontario

    LeBelle, MJ
    Research Scientist, Research Technologist, Undergraduate Student and Research Scientist, Pharmaceutical Chemistry Division, Bureau of Drug Research, Health Protection Branch, Ottawa, Ontario


    Stock #: JFS13681J

    ISSN: 0022-1198

    DOI: 10.1520/JFS13681J

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    Title Nuclear Magnetic Resonance Identification of the Phenylalkylamine Alkaloids of Khat Using a Chiral Solvating Agent
    Symposium , 0000-00-00
    Committee E30