ISSN: 0022-1198
CODEN: JFSCA
Page Count: 6

A Fatality Involving Clothiapine and Clomipramine
Bono, GD
Assistant, Ospedale Civile E. Muscatello, Servizio di Anestesia e Rianimazione,

Romano, G
Associate Professor of Forensic Toxicology, Istituto di Medicina Legale e delle Assicurazioni, Università di Catania,

(Received 7 July 1993; accepted 23 November 1993)

Abstract

A fatality resulting from the suicidal ingestion of clothiapine, clomipramine and biperiden is reported. Clomipramine, its metabolite N-desmethylclomipramine and clothiapine were quantified in blood, liver, kidney and gastric contents by HPLC and GC. Biperiden was detected only in the gastric content. Significant differences of drug levels were found in postmortem blood obtained from brain and from heart. Concentrations of clomipramine and N-desmethylclomipramine ranged from 0.48 to 1.61 mg/L and 0.26 to 1.32 mg/L, respectively, and clothiapine from 0.50 to 2.15 mg/L. This phenomenon may reflect a postmortem drug redistribution.

Keywords:
toxicology, clothiapine, clomipramine, chromatographic analysis

Paper ID: JFS13668J
DOI: 10.1520/JFS13668J
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