ISSN: 0022-1198
CODEN: JFSCA
Page Count: 8

The Routine Analysis of Breast Milk for Drugs of Abuse in a Clinical Toxicology Laboratory
Lind, A
Creighton University School of Medicine, NE

Therkildsen, D
Creighton University School of Medicine, NE

Nipper, HC
Creighton University School of Medicine, NE

Makoid, M
Creighton University School of Pharmacy and Allied Health, NE

Dickson, PH
Creighton University School of Medicine, NE

Studts, P
Saint Joseph Hospital, Dept. of Pathology, NE

(Received 21 July 1992; accepted 1 June 1993)

Abstract

Drug screening of breast milk in a clinical toxicology laboratory is reported. Findings from three cases include cocaine, ethylbenzoylecgonine (cocaethylene), ethanol, oxycodone, codeine, and nicotine. We believe this to be the first report of ethylbenzoylecgonine in human breast milk. One other specimen submitted for analysis was screened with negative results. Screening and confirmation procedures adapted for use with breast milk are described. Finally, the potential for cocaine intoxication from mother to baby is discussed. Estimates of infant blood cocaine concentration are given which may increase awareness of the need to monitor milk and blood cocaine concentrations in the infant when the situation warrants.

Keywords:
toxicology, breast milk, drug analysis, cocaine, ethylbenzoylecgonine, cocaethylene, ethanol, nicotine, codeine, caffeine, pharmacokinetics, infant intoxication, breast feeding

Paper ID: JFS13586J
DOI: 10.1520/JFS13586J
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