The Determination of Anabolic Steroids by MECC, Gradient HPLC, and Capillary GC

    Volume 39, Issue 1 (January 1994)

    ISSN: 0022-1198

    CODEN: JFSOAD

    Page Count: 12


    Sperling, AR
    Senior Research Chemists and Forensic Chemist, Special Testing and Research Laboratory, Drug Enforcement Administration, McLean, VA

    Lurie, IS
    Senior Research Chemists and Forensic Chemist, Special Testing and Research Laboratory, Drug Enforcement Administration, McLean, VA

    Meyers, RP
    Senior Research Chemists and Forensic Chemist, Special Testing and Research Laboratory, Drug Enforcement Administration, McLean, VA

    (Received 29 March 1993; accepted 3 July 1993)

    Abstract

    Methodologies are presented for the qualitative and quantitative determinations of anabolic steroids in forensic exhibits using micellar electrokinetic capillary chromatography (MECC), high performance liquid chromatography (HPLC) and capillary gas chromatography (GC). Analyses of representative pharmaceutical dosage forms (including a commercial aqueous suspension, a commercial tablet, several commercial oil samples and various simulated dosage units) were performed using a simple, one step quantitative extraction procedure with methanol. Good agreement was obtained between all three techniques. Retention, migration and linearity data are presented and compared for over twenty anabolic steroids commonly encountered in forensic exhibits. A principal component analysis study confirmed the orthogonality of the three techniques.


    Paper ID: JFS13572J

    DOI: 10.1520/JFS13572J

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    Title The Determination of Anabolic Steroids by MECC, Gradient HPLC, and Capillary GC
    Symposium , 0000-00-00
    Committee E30