Volume 39, Issue 1 (January 1994)

    Comments on the Statistical Aspects of the NRC's Report on DNA Typing

    (Received 30 November 1992; accepted 25 June 1993)

    CODEN: JFSOAD

      Format Pages Price  
    PDF 13 $25   ADD TO CART


    Abstract

    The goal of the NRC report on DNA typing was to answer a “crescendo of questions concerning DNA typing,” many of them in the areas of population genetics and statistics. Unfortunately, few of these questions were answered adequately. In lieu of answering these questions, the panel proposed another conservative method of forensic inference, the “ceiling principle.” Aside from its extreme conservativeness, this new method is difficult to justify because it is based on inadequate population genetics and statistical theory. Moreover, in its ultimate implementation, the panel's method will depend on a population genetics study whose rationale is questionable. In this article, we elaborate some of the general comments we made about the NRC report in a recent article [1]. Specifically we cover three topics. First we question the statistical basis for the ceiling principle, showing that the empirical results that motivated the method are likely to be misinterpreted and showing, by power calculations, that the effects of population substructure cannot be substantial. Second, we show that the study design to determine “ceiling” allele frequencies has several undesirable statistical properties. Finally, we discuss the estimation of handling errors from the statistical perspective, a subject treated inadequately by the report.


    Author Information:

    Devlin, B
    Yale University School of Medicine, New Haven, CT

    Roeder, K
    Yale University,

    Risch, N
    Yale University School of Medicine,


    Stock #: JFS13568J

    ISSN: 0022-1198

    DOI: 10.1520/JFS13568J

    ASTM International
    is a member of CrossRef.

    Author
    Title Comments on the Statistical Aspects of the NRC's Report on DNA Typing
    Symposium , 0000-00-00
    Committee E30