Journal Published Online: 01 November 1993
Volume 38, Issue 6

Evaluation of HLA in Detection of Non-Parentage Among Known False Trios

CODEN: JFSCAS

Abstract

This paternity study was performed with trios in which the putative father was not the biological father (NBF), in order to evaluate the effectiveness of HLA-A and -B phenotyping for routine testing.

All 372 generated trios had ABO, Rh, MNS, Kell, Duffy, Kidd and HLA (A and B) systems tested.

HLA-A and -B phenotyping directly excluded 81.73% of NBF. Red blood cell markers excluded 8.82% of NBF missed by HLA; only 0.81% of NBF were not identified by the markers used.

Each laboratory engaged in disputed paternity testing should evaluate its actual performance in detecting non-biological fathers and its exclusion rates in real trios. These data together can be used as a guide of mother's reliability.

Author Information

Salaru, NNR
Instituo Medicina Social Criminologia São Paulo, São Paulo, Brazil
Pages: 4
Price: $25.00
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Stock #: JFS13554J
ISSN: 0022-1198
DOI: 10.1520/JFS13554J